| Administrator | Rev. Stephen D. Dyas | (843) 768-0357 | |
| Deacon | Mario Cardenas | (843) 768-0357 | |
| Deacon | RJ Dourney | (843) 768-0357 | rjdourney@holyspiritsc.org |
| Deacon | John Hardy | (843) 768-0357 | jhardy@holyspiritsc.org |
| Deacon | Chris Mathewes | (843) 768-0357 | |
| Deacon | Joe Stocker | (843) 768-0357 | jstocker@holyspiritsc.org |
| Financial Secretary | (843) 768-0357 | financial.secretary@holyspiritsc.org | |
| Parish Secretary | Jeanne Davis | (843) 768-0357 | office@holyspiritsc.org |
| Music Director | (843) 768-0357 | ||
| Faith Formation | Beth Mathewes | (843) 768-0357 | bmathewes@holyspiritsc.org |
| Faith Formation | Ana Tovar (Hispanic) | (843) 768-0357 | atovar@holyspiritsc.org |
| Director of Communications | David Piccirilli | (843) 768-0357 | dpiccirilli@holyspiritsc.org |
| Operations Associate | Stephanie Hamilton | (843) 768-0357 | shamilton@holyspiritsc.org |
| Diocesan Office of Child Protection Services | (843) 853-2130 x 209 | ||
| Diocesan Victim Assistance Ministry | (800) 921-8122 |